Research shows that supplemental Glutathione both increases stamina and delays fatigue during strenuous, prolonged exercise in endurance-trained individuals. The benefits appear to be linked to increased serum Glutathione and benefits are seen within 24 hours of administration but also are persistent and cumulative with additional treatments. 1 gram by push IV weekly, preferably 24 hours before an event. Higher doses, up to 2 grams should be more effective in highly trained individuals.
Interesting case study
http://www.hammernutrition.com/downloads/glutathione_tt.pdf
Highlights:
ABSTRACT
A healthy, fit 61-year old male endurance athlete received four (4 each) intravenous
glutathione treatments consisting of 100 mg/cc, using 10cc (total 1000 milligrams)
diluted total of 20cc normal saline solution slow IV-push delivery (15 minutes). The
tests were recorded 36-days during a previously established aerobic cycling fitness
on a common course. There were no changes in training or dietary protocols other
than the administration of glutathione intravenously. The subject's pre-treatment
timed-trial was 57:30 (minutes:seconds). Performance improved progressively
following each of 4 separate intravenous treatments to a peak performance of
52:21(minutes:seconds), representing a remarkable performance gain of 7.2%. The
only variable to account for this performance gain was the intravenous glutathione
treatments.
Exhaustive exercise depletes glutathione and simultaneously generates free radicals.
This is evidenced by increases in lipid peroxidation, glutathione oxidation, and
oxidative protein damage. It is well known that activity of cytosolic enzymes in
blood plasma is increased as a result of exhaustive exercise
CONCLUSION
Performance gain 7-10 days after treatment #1 was significant (+2.1%) with total
performance gains from intravenous glutathione +7.2% over 36 days (57:30 to
52:21 minutes:seconds), averaging a remarkable +1.8% per treatment
administered. The only variable to account for the remarkable improvement in
performance was four glutathione injections. Measure of the efficiency of oxygen
metabolization is closely tied to the mechanism of rapid glutathione repletion to
resolve depleted levels. By increasing GSH serum levels, enhanced performance
may result. Further research is needed with aging, fit, healthy subjects, measuring a
variety of physiologic and metabolic endpoints to determine if the results of this
case study prevail, and if so, the mechanism of any such benefits achieved.
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